After being sent to Gitmo to gather evidence for a murder case concerning a chaplain with the United States Navy, Bishop begins questioning her previous work with the NSA while her three brothers visit for the Thanksgiving holiday and pester her co-workers at NCIS in an attempt to find out who she's dating.
- Bishop's other two older brothers, John and Robert are introduced for the first time.
- It's revealed that Bishop's brothers egged Jake Malloy's car.
- Everyone soon learns that Bishop is dating NCIS translator Qasim Naasir.
- This is also the first episode of the entire NCIS series to have the names of both Frank Cardea and George Schenck appear at the end credits followed by late Executive Producer Gary Glasberg and former Executive Producer Donald P. Bellisario. This is because Cardea and Schenck are the new showrunners for NCIS, replacing Glasberg who died suddenly in September 2016.
|Leroy Jethro Gibbs||Mark Harmon||Special Agent in charge of the NCIS Major Case Response Team.|
|Abigail Sciuto||Pauley Perrette||Chief Forensic Specialist for the NCIS Major Case Response Team.|
|Timothy McGee||Sean Murray (actor)||Senior Special Agent and second-in command of the NCIS Major Case Response Team.|
|Nicholas Torres||Wilmer Valderrama||Special Agent for the NCIS Major Case Response Team.|
|Alexandra Quinn||Jennifer Esposito||Special Agent for the NCIS Major Case Response Team.|
|Eleanor Bishop||Emily Wickersham||Probationary Agent for the NCIS Major Case Response Team.|
|James Palmer||Brian Dietzen||Assistant Medical Examiner for the NCIS Major Case Response Team. Despite being credited, Dietzen does not appear in this episode, with Ducky explaining that Palmer had a leave of absence due to an accident with the turkey that presumably left him non-fatally yet still seriously injured.|
|Leon Vance||Rocky Carroll||Director of NCIS.|
|Donald Mallard||David McCallum||Chief Medical Examiner for the NCIS Major Case Response Team.|
|Clayton Reeves||Duane Henry||Officer with MI6.|
|George Bishop||Ryan Doom||Bishop's older brother.|
|Qasim Naasir||Rafi Silver||NCIS Translator.|
|John Bishop||Jesse Bradford||Bishop's older brother.|
|Robert Bishop||Jesse Johnson||Bishop's older brother.|
|Amir Hassan||Aaron Ramzi||Brother of Samira Hassan|
|Rick Ayers||John Charles Meyer||The real name of Brendan Peters|
|Gareth Bainbridge||Evan Arnold|
|Holt Driscoll||Jim Abele||Army Colonel at Gitmo|
|Mary Messier||Kira Sternback|
|Keith Messier||Charlie Bodin|
|Samira Hassan||Odelya Halevi||Sister of Amir Hassan|
|Tom Healy||David Bittick||Army Sergeant.|