Handle With Care is the 16th episode of NCIS Season 15 and also the 346th episode of the entire NCIS series.
Gibbs and the team work to clear the name of retired Marine Sergeant John Ross when cyanide is found in one of the hundreds of care packages he sends to active-duty Marines.
- Clips from this episode were later shown in the 48 Hours: NCIS Season 3 episode Heartless, which dealt with a similar murder.
- Drew Carey (John Ross) is credited as a Special Guest Star.
|Leroy Jethro Gibbs||Mark Harmon||Special Agent in charge of the NCIS Major Case Response Team.|
|Abigail Sciuto||Pauley Perrette||Chief Forensic Specialist for the NCIS Major Case Response Team.|
|Timothy McGee||Sean Murray||Senior Special Agent and second-in command of the NCIS Major Case Response Team.|
|Nicholas Torres||Wilmer Valderrama||Special Agent for the NCIS Major Case Response Team.|
|Eleanor Bishop||Emily Wickersham||Special Agent for the NCIS Major Case Response Team.|
|James Palmer||Brian Dietzen||Assistant Medical Examiner for the NCIS Major Case Response Team.|
|Leon Vance||Rocky Carroll||Director of NCIS.|
|Jacqueline Sloane||Maria Bello||NCIS Special Agent.|
|Donald Mallard||David McCallum||Chief Medical Examiner for the NCIS Major Case Response Team.|
|Clayton Reeves||Duane Henry||Interagency Liaison between MI6 and NCIS.|
|John Ross||Drew Carey||Retired Marine Sergeant|
|Whit Dexter||Jake Busey||Shock jock.|
|Emma Sweeney||Arienne Mandi|
|Tom Moore||Jaymes Butler|
|Molly Guinn||Joanna Leeds|
|Bob Sweeney||Kirk Baltz|
|James Sweeney||Jake Allyn||Navy Petty Officer Second Class and murder victim.|
|Albert Dale||Shaun Clay||Navy Petty Officer Third Class.|
|Clyde Sweeney||Mike Maolucci|
|Gordon Cooper||Tyler Parks||Navy Petty Officer Third Class.|